Local Anesthetics agents. #anesthesia #pharmacology #pharmacology #pharma

Local anesthetic agents block the sodium

channels and prevent the generation and

propagation of action potential so that

the sensations cannot be transmitted

from the source of stimulation to the

brain. We classify them into two main

groups based on their chemical linkage.

One esters short acting more allergic

reactions metabolized by plasma

colonsterase.

Examples cocaine procine tetraane

benzicaine. Tip one I in the name equals

Esther. Two amides longer acting fewer

allergies metabolized in the liver.

Examples lidocaine, bupivocaine,

mapivocaine, pryloane. Tip two, I