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How to Increase Motivation & Drive | Huberman Lab Essentials

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welcome to huberman lab Essentials where

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we revisit past episodes for the most

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potent and actionable science-based

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tools for mental health physical health

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and

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performance I'm Andrew huberman and I'm

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a professor of neurobiology and

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Opthalmology at Stanford school of

0:16

medicine today we're going to talk about

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an extremely important topic that's

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Central to our daily life and that's

0:23

motivation we're going to talk about

0:25

pleasure and reward what underlies our

0:27

sense of pleasure or reward we're going

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to talk about addictions as well we're

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going to talk about the neurochemistry

0:35

of drive and mindset but for now let's

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just talk about the Neuroscience of

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motivation and reward of Pleasure and

0:42

Pain because those are Central to what

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we think of as emotions whether or not

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we feel good whether or not we feel

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we're on track in life whether or not we

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feel we're falling behind so motivation

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is fundamental to our daily life it's

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what allows us to get out of bed in the

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morning it's what allows us to pursue

0:59

longterm goals or short-term goals

1:02

motivation and the chemistry of

1:04

motivation is tightly wound in with the

1:08

neurochemistry of movement in fact the

1:11

same single molecule dopamine is

1:14

responsible for our sense of motivation

1:17

and for movement it's a fascinating

1:20

molecule and it lies at the center of so

1:23

many great things in life and it lies at

1:26

the center of so many terrible aspects

1:28

of Life namely addiction and certain

1:30

forms of mental disease so if ever there

1:32

was a double-edged blade in the world of

1:36

Neuroscience it's dopamine there's a

1:38

fundamental relationship between

1:40

dopamine released in your brain and your

1:42

desire to exert effort and you can

1:45

actually control the schedule of

1:47

dopamine release but it requires the

1:49

appropriate knowledge this is one of

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those cases where understanding the way

1:53

the dopamine system works will allow you

1:54

to leverage it to your benefit let's get

1:56

a few basic facts on the table dopamine

2:00

was discovered in the late 1950s and it

2:03

was discovered as the precursor meaning

2:06

the thing from which epinephrine or

2:08

adrenaline is made epinephrine is the

2:11

same thing as adrenaline except in the

2:13

brain we call it epinephrine

2:15

epinephrine allows us to get into action

2:19

it stimulates changes in the blood

2:21

vessels in the heart in the organs and

2:22

tissues of the body that bias us for

2:25

movement dopamine was initially thought

2:27

to be just the building block for

2:29

epinephrine

2:30

however dopamine does a lot of things on

2:32

its own it's not always converted to

2:34

epinephrine dopamine is released from

2:37

several sites in the brain and body but

2:39

perhaps the most important one for

2:40

today's discussion about motivation and

2:42

reward is something that sometimes just

2:44

called the reward pathway for the

2:47

afficianados it's sometimes called the

2:48

misol limic reward pathway but it's

2:51

fundamentally important to your desire

2:54

to engage in action and it's

2:57

fundamentally important for people

2:59

getting addicted to substances or

3:02

behaviors so how does this work well

3:04

you've got a structure in the Deep part

3:06

of your brain called the VTA the VTA or

3:09

vental tegmental area contains neurons

3:12

that send what we call axons little

3:14

wires that spit out dopamine at a

3:17

different structure called the nucleus

3:19

accumbent and those two structures VTA

3:21

and nucleus accumbent form really the

3:24

core Machinery of the reward pathway and

3:27

the pathway that controls your

3:28

motivation for anything you can think of

3:31

them like an accelerator they bias you

3:34

for Action however within the reward

3:37

pathway there's also a break the break

3:39

or restriction on that dopamine which

3:41

controls when it's released and how much

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it's released is the prefrontal cortex

3:46

the prefrontal cortex is the neural real

3:48

estate right behind your forehead you

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hear about it for decisionmaking

3:52

executive function for planning Etc and

3:55

indeed it's responsible for a lot of

3:56

those it's this really unique real

3:58

estate that we were all endowed with as

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humans other animals don't have much of

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it we have a lot of it and that

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prefrontal cortex acts as a break on the

4:06

dopamine system and that brings us to

4:09

the important feature of motivation

4:11

which is that motivation is a two-part

4:13

process which is about balancing

4:16

Pleasure and Pain so when you're just

4:19

sitting around not doing much of

4:20

anything this reward pathway is

4:23

releasing dopamine at a rate of about

4:25

three or four times per second it's kind

4:27

of firing in a low level if suddenly you

4:30

get excited about something you

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anticipate something not receive an

4:34

award but you get excited in an

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anticipatory

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way then the rate of firing the rate of

4:41

activity in this reward pathway suddenly

4:44

increases to like 30 or 40 times and it

4:47

has the effect of creating a sense of

4:50

action or desire to move in the

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direction of the thing that you're

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craving in fact it's fair to say that

4:55

dopamine is responsible for wanting and

4:58

for craving and that's distinctly

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different from the way that you hear it

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talked about normally which is that it's

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involved in pleasure so yes dopamine is

5:06

released in response to sex it's

5:08

released in response to food it's

5:10

released in response to a lot of things

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but it's mostly released in anticipation

5:15

and craving for a particular thing it

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has the effect of narrowing our Focus

5:20

for the thing that We crave and that

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thing could be as simple as a cup of

5:23

coffee it could be as um important as a

5:26

big board meeting it could be a big

5:27

final exam it could be uh the person

5:29

that we're excited to meet or see

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dopamine doesn't care about what you're

5:34

craving it just releases at a particular

5:36

rate if we just take a step back and we

5:38

look at the scientific data on how much

5:42

the dopamine firing increases in

5:44

response to different things you get a

5:46

pretty interesting window into how your

5:49

brain works and why you might be

5:50

motivated or not motivated let's say

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you're hungry or you're looking forward

5:54

to a cup of coffee or you're going to

5:57

see your partner well well your dopamine

6:00

neurons are firing at a low rate until

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you start thinking about the thing that

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you want or the thing that you're

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looking forward to when you eat that

6:08

food the amount of dopamine that's

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released in this reward pathway goes up

6:12

about 50% above

6:15

Baseline sex which is fundamental to our

6:18

species continuation and reproduction

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sex does release dopamine and it

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increases dopamine levels about 100% so

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basically doubles them Nic

6:30

increases the amount of dopamine about

6:32

150% above Baseline cocaine and

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amphetamine increase the amount of

6:37

dopamine that's released a thousandfold

6:39

within about 10 seconds of consuming the

6:42

drug however just thinking about food

6:46

about

6:46

sex about nicotine if you like nicotine

6:50

or cocaine or amphetamine can increase

6:52

the amount of dopamine that's released

6:54

to the same degree as actually consuming

6:57

the drug now it depends in some cases

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for instance the cocaine user the addict

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that wants cocaine can't just think

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about cocaine and increase the amount of

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that's released about a thousandfold

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it's actually much lower but it's just

7:10

enough to put them on the motivation

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track for to Crave that particular thing

7:15

now there are reasons why you would have

7:16

brain circuitry like this I mean brain

7:18

circuitry like this didn't evolve to get

7:19

you addicted brain circuitry like this

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evolved in order to motivate behaviors

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toward particular goals water when

7:28

you're thirsty sex and in order to

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reproduce these things and these brain

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areas and neurons were part of the

7:35

evolutionary history that led to the

7:37

continuation of our species things like

7:40

cocaine and amphetamine are disastrous

7:42

for most people because they release so

7:44

much dopamine and they create these

7:46

closed Loops where people then only

7:48

crave the particular thing cocaine

7:50

amphetamine that leads to those massive

7:53

amounts of dopamine release most things

7:55

don't release that that level of

7:57

dopamine now nowadays there's a ton of

7:59

Interest in social media and in video

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games and it there have been some

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measurements of the amount of dopamine

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released video games especially video

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games that have a very high update speed

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where there's novel territory all the

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time novelty is a big stimulus of

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dopamine those can release dopamine

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somewhere between nicotine and cocaine

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so very high levels of dopamine release

8:22

social media is an interesting one

8:24

because the amount of dopamine that's

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released in response to logging onto

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social media initi could be quite high

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but it seems like likely that there's a

8:33

taper in the amount of dopamine but and

8:35

yet people still get addicted so why why

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is it that we can get addicted to things

8:40

that fail to get to elicit the same

8:42

massive amount of pleasure that they

8:44

initially did being addicted to

8:46

something isn't just about the fact that

8:48

it feels so good that you want to do it

8:50

over and over again and that's because

8:52

of this pleasure pain balance that

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underlies motivation so let's look a

8:56

little bit closer at the pleasure pain

8:58

balance because therein lies the tools

9:01

for you to be able to control motivation

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toward healthy things and avoid

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motivated behaviors towards things that

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are destructive for you there are a lot

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of reasons why people try novel

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behaviors whether not those are drugs or

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whether not those are Adventure

9:14

thrill-seeking things or you know they

9:16

take a new class as you'll notice I'm

9:18

not placing any judgment or value on

9:20

these different behaviors although I

9:22

think it's fair to point out that for

9:24

most

9:25

people addictive drugs like cocaine and

9:27

amphetamine are very

9:30

destructive actually we know that about

9:32

15 to 20% of people have a genetic bias

9:37

towards addiction that you know you

9:40

sometimes hear that the first time that

9:41

you use a drug you can become addicted

9:43

to it that's actually not been shown to

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be true for most things and most people

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but for some people that actually is

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true but in any case the way that

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addiction works and the way that

9:53

motivation Works generally in the

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non-addictive setting is that when you

9:57

anticipate something a little bit of

9:58

dopamine is released and then when you

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reach that thing you engage in that

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thing the amount of dopamine goes up

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even further but as you repeatedly

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pursue a behavior and you repeatedly

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engage with a particular thing let's say

10:11

you love running or you love chocolate

10:14

as you eat a piece of chocolate believe

10:17

it or not it tastes good and then

10:19

there's a shift away from activation of

10:22

dopamine and there are other chemicals

10:24

that are released that trigger a

10:27

low-level sense of pain now you you

10:29

might not feel it as physical pain but

10:31

the craving that you feel is both one

10:34

part dopamine and one part the mirror

10:36

image of dopamine which is the pain or

10:39

the craving for yet another piece of

10:41

chocolate and this is a very important

10:43

and subtle feature of the dopamine

10:45

system that's not often discussed people

10:47

always talk about just as pleasure you

10:49

love social media so it gives you

10:51

dopamine and so you engage in that you

10:53

like chocolate it releases dopamine so

10:54

you do that but for every bit of

10:56

dopamine that's released there's another

10:58

circuit in the brain

10:59

that creates you can think of it as kind

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of like a downward deflection in

11:03

pleasure so you engage in something you

11:04

really want and there's an increase in

11:06

pleasure and then there's a without you

11:10

doing anything there's a mirror image of

11:12

that which is a downward deflection and

11:14

pleasure which we're calling pain so for

11:16

every bit of pleasure there is a mirror

11:18

image experience of pain and they

11:20

overlap in time very closely so it's

11:22

sometimes hard to sense this but try it

11:24

the next time you eat something really

11:25

delicious you'll take a bite it tastes

11:27

delicious and part of experience is to

11:30

want more of that thing this is true for

11:32

any pleasureful

11:34

experience now the Diabolical part about

11:36

dopamine is that because it didn't

11:39

evolve in order to get you to indulge in

11:41

more and more and more of something what

11:44

happens is that initially you experience

11:48

an in an increase in pleasure and you

11:51

also experience this increase in pain

11:53

shortly after or woven in with the

11:55

pleasure that makes you want more of

11:57

that thing but with each subsequent time

12:01

that you encounter that thing the

12:03

experience of dopamine release and

12:05

pleasure is diminished a little bit and

12:09

the Diabolical thing is that the pain

12:11

response is increased a little bit and

12:14

this is best observed in the context of

12:16

drug-seeking behavior the first time

12:18

someone decides to take cocaine or

12:20

amphetamine they will experience a huge

12:22

dopamine release and they will feel

12:24

likely very good however the next time

12:27

they take it it won't feel quite as good

12:29

and it won't feel even as good the third

12:31

time or the next time but the amount of

12:35

pain the amount of craving that they

12:37

experience for the drug will increase

12:39

over time so much of our pursuit of

12:41

pleasure is simply to reduce the pain of

12:44

craving so the next time you experience

12:46

something you really like I don't want

12:48

to take you out of that experience but

12:49

it's really important that you notice

12:51

this that if there's something you

12:53

really enjoy part of that enjoyment is

12:56

about the anticipation and wanting of

12:58

more of that thing and that's the pain

13:01

system in action and so we can

13:03

distinguish between dopamine which is

13:05

really about pleasure and dopamine which

13:06

is really about motivation to pursue

13:08

more in order to relieve or exclude

13:12

future pain let me repeat that dopamine

13:14

isn't as much about pleasure as much as

13:16

it is about motivation and desire to

13:19

pursue more in order to reduce the

13:22

amount of pain and we are now talking

13:25

about pain as a psychological pain and a

13:27

craving although people that Miss a

13:30

lover very badly or that really crave a

13:34

food very badly or that are addicted to

13:38

a drug and can't access it will

13:40

experience that as a physical craving

13:42

and a mental craving the body and brain

13:44

are linked in this way it's almost

13:46

they'll describe it as painful they

13:48

yearn for it and I think the word

13:50

yearning is one that's very valuable in

13:52

this context because yearning seems to

13:54

include a whole body experience more

13:57

than just wanting which could just be up

13:58

in the mind mind so your desire for

14:02

something is proportional to how

14:05

pleasureful it is to indulge in that

14:07

thing but also how much pain you

14:09

experience when you don't have it and

14:11

you can now start to let your mind

14:13

wander into all sorts of examples of

14:15

addictions or things that you happen to

14:16

like um I'll use the example that I

14:18

sometimes use on here which is my love

14:20

of croissants the taste of that

14:21

croissant makes me want to eat more

14:23

croissant now eventually blood sugar

14:25

goes up satiety is reached Etc what

14:27

happens then what is s isfaction and

14:29

satiety about well that's a separate

14:31

neuromodulator that's about the

14:33

neuromodulator serotonin it's about

14:36

oxytocin it's about a hormone system

14:39

that involves something called prolactin

14:40

so we're going to talk about all all of

14:42

those in the book The molecule of more

14:44

wonderful book uh those were described

14:47

as the Here and Now molecules the ones

14:49

that allow you to experience your

14:51

Sensations and pleasure in the present

14:53

and for which the brain stops projecting

14:55

into the future so now let's talk about

14:57

craving and and the these so-called Here

14:59

and Now molecules and how those engage

15:02

in a kind of pushpull balance that will

15:04

allow you to not just feel more

15:06

motivated but also to enjoy the things

15:08

in life that you are pursuing to a much

15:11

greater degree we have neurons in an

15:13

area of our brain called the rap r a p

15:15

he e the RAF releases serotonin at

15:19

different places in the brain serotonin

15:22

is the molecule of bliss and contentment

15:25

for what you already have I've talked

15:28

before about exteroception exteroception

15:31

is a focus on the outside world

15:32

everything beyond the confines of your

15:34

skin I've also talked about

15:36

interoception a focus on things that are

15:38

happening internally within the confines

15:40

of your

15:41

skin dopamine and

15:45

serotonin can be thought of as related

15:48

to exteroception dopamine makes us

15:50

focused on things outside us that are

15:52

beyond what we call our personal space

15:54

where we actually have to move and take

15:57

action in order to achieve things

15:59

and serotonin in general has to do with

16:01

the things that are in our immediate

16:03

Here and Now hence the description of

16:04

these as the Here and Now molecules so

16:07

it's interesting to point out that the

16:10

body and the Brain can direct its

16:12

attention towards things outside us or

16:14

inside us or split our attention between

16:16

those just understand that dopamine

16:18

biases us toward thinking about what we

16:20

don't have whereas serotonin and some of

16:23

the related molecules like the endoc

16:25

canabo if you picked up on the word

16:27

cannabinoid yes it's like cannabis

16:29

because cannabis attaches to endoc

16:31

canabo receptors and the endoc canabo

16:34

are receptors and chemicals that the

16:36

cannabinoids that you naturally make

16:38

that are involved in things like

16:39

forgetting but you make these molecules

16:42

that bind to these receptors that make

16:43

you feel kind of bliss out and content

16:45

in the present so you got these two

16:47

systems they're kind of like a push pull

16:50

and if you were to say do the um you

16:52

know in the book wherever you go there

16:54

you are John katzin talks about this

16:56

meditation practice that's different

16:57

than most meditation prct ractic is

16:59

where you eat one almond and you focus

17:01

all of your attention on the Almond the

17:03

taste of the Almond the texture of the

17:05

Almond that's really a mindfulness

17:08

practice that's geared towards trying to

17:09

take a behavior which is normally about

17:12

Pursuit normally feeding is we going we

17:15

engage in feeding because of dopamine we

17:18

pursue more of a food because of that

17:19

pleasure pain relationship I talked

17:20

about before the focus on the one almond

17:23

or the or becoming very present in any

17:26

behavior that normally would be a kind

17:28

of extra receptive Pursuit behavior and

17:31

bring it into the here and now that's a

17:34

mental trick or a mental task that the

17:38

mindfulness Community has really

17:40

embraced in order to try and create

17:41

increased pleasure for what you already

17:43

have it's really trying to accomplish a

17:46

shift from dopamine being released to

17:48

serotonin in the cannabinoid system

17:51

being involved in that behavior dopamine

17:53

has the quality of making people kind of

17:55

rabidly in pursuit of things drugs like

17:59

marijuana the opioids anything that um

18:04

really hits the serotonin system hard

18:06

tend to make people rather lethargic and

18:08

content to stay exactly where they are

18:10

they don't want to pursue much at all so

18:12

you've got these molecules like dopamine

18:14

that make you focused on the things you

18:16

want and the things you crave and then

18:18

you've got the molecules that make you

18:19

content with what you have so the most

18:22

important thing perhaps in creating a

18:25

healthy emotional landscape is to have a

18:27

balance between these two neuromodulator

18:30

systems so at about this point in the

18:31

podcast I'm guessing that some of you

18:33

are thinking okay great I want more

18:35

dopamine I want to be more motivated I

18:37

don't want to procrastinate as much and

18:40

I want to be able to experience life I

18:42

want these Here and Now molecules to be

18:43

released as well well there is a way to

18:45

do that but you have to understand the

18:47

source of procrastination is not one

18:50

thing there are basically two kinds of

18:52

procrastinators or so says the research

18:55

the first kind are people that actually

18:57

really enjoy the stress of the impending

19:01

deadline it's the only way they can get

19:03

into action there are other

19:04

procrastinators for which they simply

19:06

are not releasing enough dopamine for

19:08

those people there are a variety of

19:10

things that can increase dopamine I do

19:11

suggest you talk to a psychiatrist or

19:13

doctor I've talked about makuna purines

19:15

which is

19:17

99.9% L Doopa the precursor to dopamine

19:21

there are anti-depressants like

19:23

Wellbutrin Bryon is the other name for

19:26

it which increase dopamine and

19:27

epinephrine

19:29

however if you think back to our earlier

19:31

discussion about

19:33

dopamine dopamine if it's very high

19:37

creates a sense of pleasure and the

19:39

desire for more so you can also become a

19:42

person for which enough is Never Enough

19:45

the only thing that dopamine really

19:47

wants is more of the thing that releases

19:49

dopamine and so one of the things that

19:51

you can do in order to generally just be

19:53

a happier person especially if you're a

19:55

person in pursuit of long-term goals of

19:57

any kind is the longer that you can

20:00

extend that positive phase of the

20:03

dopamine release and the more that you

20:05

can blunt the pain response to that the

20:08

better and you can actually do this

20:09

cognitively I used to joke with my lab

20:11

that when we'd publish a paper I would

20:13

get really excited but I wouldn't allow

20:15

myself to get too excited what I wanted

20:17

to do instead and what I've still tried

20:19

to do is try and extend the Arc of that

20:22

positive experience as long as I

20:23

possibly can simply by thinking back

20:25

like oh that was really cool I really

20:26

enjoy doing that work I really enjoyed

20:29

the discovery I really enjoyed doing

20:30

that with the people that I was working

20:33

with at the time what a pleasure that

20:34

was so you can extend pleasure without

20:37

having to engage in the behavior over

20:39

and over that's extending the Arc of

20:41

that dopamine release as well it offsets

20:44

some of the pain of not having that

20:47

experience occur over and over and over

20:49

again now for the high performers out

20:51

there you're probably familiar with this

20:53

many people who have a big achievement

20:55

their first thoughts are well now what

20:56

what am I going to do next how am I ever

20:58

going to exceed that and indeed many

20:59

people who are very high on this kind of

21:02

dopamine sensation and novelty-seeking

21:04

scale uh are prone to addiction they're

21:06

prone to the Rabid pursuit of external

21:08

goals of exter reception to the neglect

21:11

of these internal mechanisms that allow

21:13

them to feel calm and happy so for

21:15

people that are very driven very

21:18

motivated adopting a practice of being

21:20

able to engage in the here and now the

21:22

sort of omen type practices we talked

21:24

about earlier um of learning how to

21:27

achieve a really good night's sleep on a

21:29

regular basis through tools and

21:30

mechanisms I talked about in previous

21:32

podcast gives us sort of balance to the

21:35

pleasure seeking and offsetting of pain

21:38

and the pleasure in the here and now so

21:40

pleasure is really two things it's a joy

21:43

in

21:44

Pursuit but it's also the joy in what

21:46

you have the cool thing is you can

21:49

actually regulate this whole system in a

21:51

way that will steer you or lean you

21:55

towards more positive anticipation of

21:57

things in life and less disappointment

21:59

it's simply a matter of adjusting what

22:01

we call the dopamine schedule in order

22:04

to understand how to control the

22:05

dopamine system how to leverage it for a

22:08

better

22:08

life you need to understand the results

22:11

of a very important

22:13

experiment this experiment was able to

22:16

separate pleasure from motivation it's a

22:20

very simple but like many simple

22:23

experiments a very elegant experiment

22:25

what they did and this has now been done

22:27

in animals and in humans

22:30

they offered rats food it was a food

22:32

that they particularly liked and the

22:35

animals would lever press for rep pellet

22:36

of food kind of classic experiment

22:38

they'd eat the food and they presumably

22:41

like the food because they were

22:42

motivated to press the lever and eat it

22:45

great they took other

22:47

rats they eliminated the dopamine

22:50

neurons you can do this by injection of

22:51

a neurotoxin that destroys these neurons

22:54

so they actually had no dopamine in

22:56

their brain they have no ability to

22:57

release dopamine

22:59

and they gave them a lever the rats

23:02

would sit there and they'd hit the lever

23:03

and they'd eat the food they're still

23:05

enjoyed the food so you say well okay so

23:08

dopamine isn't involved in motivation it

23:10

isn't involved in pleasure no it

23:12

absolutely is they could still enjoy the

23:15

food but if they moved the rat literally

23:18

one body length away from the lever what

23:21

they found was the animals that had

23:23

dopamine would move over to the lever

23:24

press it and eat and the ones the rats

23:27

that did not have dopamine available to

23:29

them wouldn't even move one body length

23:32

one rat length to the lever in order to

23:35

press it and get the food dopamine

23:37

therefore is not about the ability to

23:40

experience pleasure it is about

23:42

motivation for pleasure and so many of

23:44

you are probably thinking wow I'm not a

23:47

very motivated person like you talked

23:48

about the one kind of procrastination

23:49

earlier what about when I just feel kind

23:52

of meh about life now for some of you

23:54

there may be a real clinical depression

23:56

and you should talk to a professional

23:57

there are very good prescription drugs

24:00

that can really help people there's also

24:02

great non-drug treatments of uh

24:05

Psychotherapy and other treatments that

24:07

are being developed in addition to

24:09

psychotherapy and the various kinds of

24:10

psychoanalysis Etc that one can use I

24:13

think the data really point to the fact

24:15

that a combination of pharmacology and

24:18

talk therapies are generally best and

24:20

there are a huge range of these things I

24:22

know many of you are in these

24:23

professions so we're not going to talk

24:24

about that right now there is a compound

24:26

that's kind of interesting in the

24:27

supplement space that isn't um munan

24:30

alopa it's not El tyrosine that isn't

24:34

promoting massive releases of dopamine

24:37

or even dopamine alone but a combination

24:40

of dopamine and serotonin and it's an

24:42

intriguing molecule it's um sold over

24:44

the counter again you have to check with

24:46

your Healthcare um uh provider before

24:48

you would take anything or remove

24:50

anything that's very important but it's

24:52

phenol ethyl amine or

24:55

pea pea

24:58

or beta phenol ethyl aiming releases

25:03

dopamine at low levels but also

25:05

serotonin at low level so it's kind of a

25:07

cocktail of the motivation molecules as

25:10

well as the quote unquote Here and Now

25:12

molecules and people's response to this

25:15

varies widely but many people report

25:19

feeling heightened sense of mental

25:21

acuity well-being Etc it is a bit of a

25:24

stimulant like anything that triggers

25:26

activation of the dopamine and

25:27

norepinephrine pathway but is an

25:29

interesting supplement so now let's talk

25:30

about what is a dopamine schedule and

25:32

how you can leverage this in order to

25:35

have heightened levels of motivation but

25:37

not get so much dopamine that you're

25:39

experiencing a crash afterwards and also

25:41

so that you can experience heightened

25:43

pleasure from the various Pursuits that

25:44

you are engaged in in life and here's

25:47

the key

25:48

principle dopamine is very subjective

25:52

meaning you can either allow yourself to

25:55

experience the pleasure of reaching a

25:57

milestone of a achieving or some craving

26:00

or not it's actually pretty powerful

26:03

what one can do with the subjective

26:05

system in fact I'm going to describe you

26:07

an experiment that highlights just how

26:09

powerful the subjective readout or the

26:12

subjective interpretation of a given

26:14

experience really can be even at the

26:16

level of pharmacology and the title of

26:18

the experiment is expectation for

26:21

stimulant type modifies caffeine's

26:23

effects on mood and cognition this was

26:26

done in college students it's a f

26:28

fascinating study what they did is they

26:31

gave college students either

26:35

Placebo essentially nothing or 200

26:38

milligrams of caffeine 200 milligrams of

26:40

caffeine is about what's in a typical

26:42

coffee like a medium coffee that you

26:44

would buy a drip coffee so they took 65

26:47

undergraduate

26:48

students in college they randomized them

26:51

to either Placebo or caffeine and they

26:54

told them that they were either getting

26:57

caffeine or adero

26:59

now Aderall cognitively carries a very

27:02

different um expectation college

27:05

students know Aderall to be a much

27:07

stronger stimulant than caffeine they

27:09

know it to create a sort of high this is

27:11

the way the students described it and

27:13

they thought that it would increase

27:14

their level of focus and their ability

27:17

to perform work so what's really

27:18

interesting is there

27:20

was definitely an effect of placebo

27:22

versus caffeine that's not surprising

27:24

however right you take a placebo you may

27:26

or may not feel more alert

27:28

um but you take 200 milligrams of

27:30

caffeine very likely you're going to

27:31

feel very alert but there was also an

27:33

effect of whether or not the students

27:36

thought they were getting caffeine or

27:37

Aderall the subjects receiving caffeine

27:40

reported feeling more stimulated anxious

27:42

and motivated than the subjects that

27:44

received the placebo okay but the ones

27:46

that expected Aderall reported stronger

27:49

amphetamine effects they performed

27:50

better on a working memory test and in

27:53

general they had all the increased

27:56

cognitive effects that would have been

27:58

seen with adol but they were only

28:00

ingesting caffeine so it led to

28:03

heightened performance simply because

28:05

the students thought they were getting

28:07

Aderall and I think this is very

28:09

important because I think that it points

28:10

to the fact that the the the top down

28:14

the kind of higher level cognitive

28:15

processes are impacting even the most

28:17

basic fundamental aspects of say

28:20

dopamine release or our uh adrenaline

28:23

release or epinephrine release in ways

28:24

that can positively impact performance

28:26

in this case it was a positive

28:28

Improvement in working memory and focus

28:30

so today we've talked a lot about the

28:33

dopamine system and and those kinds of

28:35

schedules that will allow craving or

28:38

addiction but what's the schedule of

28:40

dopamine that's going to allow you to

28:42

maximize on your pursuit of pleasure and

28:45

your elimination of pain and we get the

28:48

answer to that from our good friend

28:51

gambling the reason gambling works the

28:54

reason why people will throw their lives

28:56

away the reason why people go back again

28:58

and again and again to places like Las

29:01

Vegas and Atlantic City is because of

29:05

the hope and anticipation it's a those

29:07

are cities and places built on dopamine

29:09

they are leveraging your dopamine system

29:11

and as a friend of mine who's a

29:13

certified addiction treatment specialist

29:15

tells me that you know gambling

29:16

addiction is a particularly Sinister

29:19

because the next time really could be

29:21

the thing that changes everything unlike

29:23

other addictions the next time really

29:25

could change everything and that's

29:26

embedded in the mind of the gambling

29:28

addict and rarely does it work out uh in

29:31

favor of the well-being of the gambling

29:32

addict and their family however the

29:36

intermittent reinforcement schedule was

29:38

discovered Long Ago by scientific

29:40

researchers so this is the slot machine

29:42

that every once in a while gives you a

29:44

win to keep you playing this is the the

29:47

probability of winning on the craps

29:49

table or the roulette table or at

29:50

Blackjack just often enough that you're

29:53

willing to buy tickets head out there

29:55

play again go downstairs again from your

29:57

room even though you swear you were done

29:58

for the night intermittent reinforcement

30:00

is the most powerful form of dopamine

30:03

reward schedule to keep you doing

30:05

something so we can export that we can

30:07

use it for good if there's something

30:10

that you're pursuing in life whether or

30:11

not it's an academic goal or a financial

30:13

goal or relationship

30:15

goal one of the things that you can do

30:17

to ensure that you will remain on the

30:19

path to that goal for a very long time

30:21

and that you will continue to exceed

30:23

your previous performance as well as

30:26

continue to enjoy the dopamine Rel that

30:28

occurs when you hit the Milestones that

30:30

you want to achieve is to occasionally

30:34

remove reward subjectively let's say you

30:38

set out a goal of making I'm going to

30:40

make this quantitative with respect to

30:41

finances because it just is an easy

30:43

description but this could also be in

30:45

sport this could be in school this could

30:46

be in music could be in anything

30:48

creative Endeavors but let's say you set

30:49

out a certain Financial goal or let's

30:52

say you want to get a certain number of

30:53

followers on whatever social media

30:55

platform as you reach each one of those

30:58

goals you should know now that the

31:00

amount of dopamine is not going to Peak

31:02

it's actually going to diminish and make

31:03

you crave more the key to avoiding that

31:06

crash but to still keep it in healthy

31:08

levels that will allow you to continue

31:10

your Pursuit is as you are staircasing

31:13

toward your goal you actually want to

31:15

blunt the reward response for some of

31:17

those intermediate goals now I'm not

31:20

telling you you shouldn't celebrate your

31:21

wins but I'm telling you not to

31:22

celebrate all of them or as a good

31:24

friend of mine who uh recently uh

31:27

fortunately for him uh had a great

31:29

financial success he asked me and

31:31

somebody else a good friend of mine

31:33

who's very tuned into dopamine reward

31:35

schedules understands how they work at a

31:37

really deep level and he said I don't

31:38

know what to do next and we said oh well

31:41

that's simple you should just give most

31:43

of it away and this wasn't a ploy to

31:45

receive any of the money ourselves this

31:47

was really about reducing the impact of

31:49

that reward now hopefully giving him

31:52

money away if you already have enough of

31:54

it would be something that was rewarding

31:56

in and of itself but if you're a student

31:58

who's pursuing goals in University or

32:01

you're an athlete who's pursuing goals

32:03

it actually makes sense from a rational

32:06

perspective once you understand these

32:08

mechanisms to hit a new high point of

32:12

performance or to get that A+ or for you

32:15

if it's an A minus Etc and to tell

32:18

yourself okay that was good but to

32:20

actually actively blunt the reward to

32:23

not go and celebrate too intensely

32:26

because in doing that you keep your

32:28

dopamine system in check and you ensure

32:31

that you're going to stay on the path of

32:33

continued Pursuit not just for that

32:34

thing but for all things big increases

32:37

in dopamine lead to big crashes in

32:39

dopamine and big increases in dopamine

32:41

up the anti so you can lift the uh what

32:45

Las Vegas and Atlantic City and other

32:47

gambling uh mechanisms and places have

32:50

known for a long time they lifted it

32:52

from the scientists you can now take it

32:54

back and you can start to leverage that

32:56

and you just make it intermittent you

32:57

reward yourself not on a predictable

33:00

schedule so not every other time or

33:02

every third time or every 10th time but

33:03

sometimes it's three in a row then not

33:05

at all for 10 days so reward is

33:09

important self-reward is critically

33:10

important but make sure that you're not

33:13

doing it on such a predictable schedule

33:15

that you burn out these dopamine

33:17

circuits or that you undercut your own

33:20

ability to strive and Achieve hopefully

33:24

you now know far more about the dopamine

33:26

system reward and motivation than you

33:29

did at the beginning of this podcast

33:31

hopefully you also understand the other

33:34

side of dopamine and reward which is

33:35

pain and the balance of this pleasure

33:37

pain system as well as the molecules

33:40

that we call or that were described in

33:42

the molecule of more book I should say

33:45

as the Here and Now molecules things

33:46

like serotonin and the endoc canabo

33:49

finally I want to thank you for your

33:50

time and attention today I hope you

33:52

learned a lot and that you learned a lot

33:54

of possible tools that you could

33:56

incorporate into your life as it relates

33:58

to motivation and emotions thank you for

34:01

your interest in science

34:05

[Music]

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